Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B

Table 2 Differentially expressed miRNAs in chronic hepatitis B patients and healthy donors

miRNA	Fold change	P value	CHB (log2) mean	Ctrls (log2) mean
hsa-miR-122	8.29	2.99E-03	8.14	5.09
hsa-miR-138	4.23	5.69E-03	2.68	0.60
hsa-miR-638	4.18	2.43E-03	12.62	10.55
hsv1-miR-H1	3.93	7.92E-03	7.67	5.70
hsa-miR-575	3.67	5.69E-03	9.59	7.71
hsa-miR-572	3.36	3.98E-03	7.58	5.83
kshv-miR-K12-3	3.34	2.60E-03	10.19	8.45
hsa-miR-1915	3.12	5.22E-03	11.30	9.66
hsa-miR-623	3.07	4.69E-03	6.85	5.23
hsa-miR-1268	2.81	6.43E-03	9.94	8.45
hsa-miR-939	2.63	3.94E-03	8.81	7.42
hsa-miR-498	2.29	4.30E-03	6.07	4.87
hsa-miR-421	0.37	4.05E-03	0.93	2.38
hsa-miR-598	0.35	5.24E-04	0.67	2.20
hsa-miR-155	0.34	6.40E-03	2.40	3.94
hsa-miR-424	0.33	9.76E-03	3.67	5.26
hsa-miR-23b	0.28	8.42E-03	5.44	7.29
hsa-miR-195	0.27	1.17E-03	1.20	3.10
hsa-miR-487b	0.26	5.46E-03	1.49	3.44
hsa-miR-224	0.25	3.71E-03	1.45	3.45
hsa-miR-495	0.24	2.50E-03	1.16	3.21
hsa-miR-181c	0.22	6.78E-03	1.88	4.03
hsa-miR-654-3p	0.21	8.27E-03	1.99	4.22
hsa-let-7e	0.21	2.52E-03	0.75	2.99
hsa-miR-382	0.21	9.11E-03	1.78	4.02
hsa-miR-171	0.19	9.66E-03	2.47	4.89
hsa-miR-128	0.18	6.17E-03	2.38	4.82
hsa-miR-625	0.18	2.70E-04	2.14	4.61
hsa-miR-30e1	0.16	2.94E-03	1.89	4.51
hsa-miR-139-5p	0.16	3.10E-03	2.39	5.03
hsa-miR-30c	0.16	8.92E-03	3.66	6.32
hsa-miR-744	0.15	9.63E-03	2.40	5.10
hsa-miR-374b	0.12	3.05E-03	2.35	5.44
hsa-miR-376c	0.11	4.32E-03	2.91	6.04

¹MicroRNA (miRNA) cloning studies sometimes identify two about 22 nt sequences miRNAs which originate from the same predicted precursor. When the relative abundancies clearly indicate which is the predominantly expressed miRNA, the mature sequences are assigned names of the form miRNA (the predominant product) and miRNA* (from the opposite arm of the precursor). For example, miR-123 and miR-123* would share a pre-miRNA hairpin, but more miR-123 would be found in the cell. In the past, this distinction was also made with "s" (sense) and "as" (antisense). CHB: Chronic hepatitis B; Ctrl: Healthy donor.