Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22

Figure 3 Levels of mRNAs encoding interleukin 22 and T helper cell 22 in lung tissue samples from rats in the sham operation, severe acute pancreatitis, and melatonin treatment groups. A: Expression of IL-22 mRNA 1, 4 and 8 h after induction of SAP; B: Expression of Th22 mRNA 1, 4 and 8 h after induction of SAP. Levels of mRNAs encoding IL-22 and Th22 decreased with continued progression of SAP (P < 0.01). ^bP < 0.01 vs the SO group; ^dP < 0.01 vs the SO and SAP groups (n = 8 rats per group). SO: Sham operation; SAP: Severe acute pancreatitis; IL: Interleukin; Th: T helper cell; MT: Melatonin treatment.