Predictors of the outcomes of acute-on-chronic hepatitis B liver failure

Table 4 Univariate and multivariate analysis of clinical and biochemical data after the first week of anti-hepatitis B virus therapy

	Univariate analysis		Multivariate analysis
	OR (95% CI)	P value	OR (95% CI)	P value
White blood cell count	5.940 (2.129-16.571)	0.001a	NI
≥ 8.50
Prothrombin time ≥ 19	4.018 (1.656-9.747)	0.002a	1.264 (0.254-6.296)	0.775
INR ≥ 2.5	3.960 (1.635-9.590)	0.002a	NI
Creatinine ≥ 0.9	4.819 (2.090-11.112)	< 0.001a	NI
Total bilirubin ≥ 15.5	4.271 (1.878-9.714)	0.001a	NI
Ammonia ≥ 166	4.167 (1.459-11.900)	0.008a	3.976 (0.703-22.482)	0.118
Serum sodium ≥ 136	3.479 (1.432-8.448)	0.006a	NI
MELD score ≥ 28	13.000 (4.604-36.711)	< 0.001a	8.182 (1.884-35.527)	0.005
APACHE-II score ≥ 14	2.941 (1.201-7.203)	0.018a	1.597 (0.375-6.809)	0.527

The parameters of white blood cell count, serum sodium, INR, total bilirubin and creatinine were not included for multivariate analyses because these parameters had been calculated for the APACHE-II score or MELD score. OR: Odds ratio; MELD: Model for end-stage liver disease; APACHE-II: Acute Physiology and Chronic Health Evaluation II; INR: International normalized ratio; NI: Not included in model.

^aP < 0.05.