Novel insight into mechanisms of cholestatic liver injury

Table 2 Murine plasma bile acid concentrations after bile duct ligation

BA	Sham control (μmol/L)	BDL 6 h (μmol/L)
TMCA	0.229 ± 0.029	1.003 ± 133
TCA	0.122 ± 0.027	1.072 ± 137
TCDCA	0.029 ± 0.003	7 ± 0.557
GCA	0.007 ± 0.0002	1 ± 0.118
GCDCA	0.003 ± 0.003	0 ± 0
αMCA	0.697 ± 0.273	87 ± 41
βMCA	0.175 ± 0.23	253 ± 100
CA	0.219 ± 0.059	17 ± 10
CDCA	0.0001 ± 0.0001	0.144 ± 0.085
TUDCA	0.031 ± 0.002	16 ± 14
TDCA	0.016 ± 0.004	0.330 ± 0.107
TLCA	0.007 ± 0.002	0.027 ± 0.002
UDCA	0.131 ± 0.002	0.492 ± 0.215
DCA	0.042 ± 0.018	0.109 ± 0.032
LCA	0.054 ± 0.013	0.033 ± 0.022

BA: Bile acid; CA: Cholic acid; CDCA: Chenodeoxycholic acid; DCA: Deoxycholic acid; GCA: Glycocholic acid; GCDCA: Glycochenodeoxycholic acid; GDCA: Glycodeoxycholic acid; LCA: Lithocholic acid; TCA: Taurocholic acid; TCDCA: Taurochenodeoxycholic acid; TLCA: Taurolithocholic acid; TUDCA: Tauroursodeoxycholic acid; UDCA: Ursodeoxycholic acid; LCA-S: Lithocholic acid sulfate; GLCA: Glycolithocholic acid; TDCA: Taurodeoxycholic acid; BDL: Bile duct ligation. Data adapted from Zhang et al[8].