Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk

Table 3 Allele and genotype frequency distribution of C150T polymorphism of the inducible nitric oxide synthetase gene in Helicobacter pylori³n (%)

	H. pylori+	H. pylori-	OR2	95%CI	P-value
iNOS C150T GC patients	n= 94	n= 65
CC	44 (46.8)	44 (67.7)	1.001
CT	40 (42.6)	19 (29.2)	2.1	1.06-4.19	0.03
TT	10 (10.6)	2 (3.1)	5	1.03-24.14	0.029
C	128 (68.1)	107 (82.3)	1.001
T	60 (31.9)	23 (17.7)	2.2	1.26-3.76	0.004
TT + CT	50 (53.2)	21 (32.3)	2.4	1.23-4.6	0.01
Controls	n = 77	n = 93
CC	40 (51.9)	52 (55.9)	1.001
CT	36 (46.8)	36 (38.7)	1.3	0.7-2.41	0.41
TT	1 (1.3)	5 (5.4)	0.26	0.03-2.31	0.197
C	116 (75.3)	140 (75.3)	1.001
T	38 (24.7)	46 (24.7)	0.99	0.61-1.64	0.99
TT + CT	37 (48.05)	41 (44.1)	1.2	0.64-2.15	0.6

¹The first allele or genotype is the reference for statistical analysis;

²Adjusted for age and gender; ³Infected or non-infected patients with and without GC. GC: Gastric cancer; iNOS: Inducible nitric oxide synthetase; CC: Homozygous CC genotype; CT: Heterozygous CT genotype; TT: Homozygous TT genotype; C: Number of individual C alleles in the group; T: Number of individual T alleles in the group; HWE: Hardy Weinberg Equilibrium; OR: Odds ratio; CI: Confidence interval; H. pylori: Helicobacter pylori.