Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk

doi:10.3748/wjg.v18.i35.4917

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Sep 21, 2012 (publication date) through Dec 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4917-4924
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4917

Table 2 Allele and genotype frequency distribution of C150T polymorphism of the inducible nitric oxide synthetase gene in patients with gastric cancer and controls n (%)

iNOS C150T	Gastric cancer n = 159	Controlsn = 170	Odds ratio	95%CI	P-value
CC	89 (56)	92 (54.1)	1.00¹
CT	59 (37.1)	72 (42.4)	0.86	0.54-1.35	0.5
TT	11 (6.9)	6 (3.5)	1.917	0.68-5.41	0.21
C allele	237 (74.5)	256 (75.3)	1.00¹
T	81 (25.5)	84 (24.7)	1.05	0.74-1.49	0.78
TT + CT	70 (44)	78 (45.9)	0.94	0.61-1.45	0.77
HWE	0.796	0.07

¹The first allele or genotype is the reference for statistical analysis. iNOS: Inducible nitric oxide synthetase; CC: Homozygous CC genotype; CT: Heterozygous CT genotype; TT: Homozygous TT genotype; HWE: Hardy Weinberg Equilibrium; CI: Confidence interval.

Citation: Rafiei A, Hosseini V, Janbabai G, Fazli B, Ajami A, Hosseini-khah Z, Gilbreath J, Merrell DS. Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk. World J Gastroenterol 2012; 18(35): 4917-4924
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4917.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4917