Use of the tumor necrosis factor-blockers for Crohn's disease

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Sep 21, 2012 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 4 Management of hepatitis B virus infection in inflammatory bowel disease patient being considered for tumor necrosis factor-α blockers therapy

Serology	Management
HBsAg+, LE ↑	Treat HBV
HbsAg+, normal LE	Vaccinate for HBV; monitor LE and HBV-DNA
HbsAg-	Vaccinate for HBV
Consider giving a combined vaccination for HAV-HBV	Measure anti-HBs-Ab titer 1 mo after third injection to determine adequacy of response; additional doses may be necessary

LE: Liver enzymes; HBV: Hepatitis B virus; HAV: Hepatitis A virus; HBsAg: Hepatitis B surface antigen.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823