Use of the tumor necrosis factor-blockers for Crohn's disease

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Sep 21, 2012 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 35 SONIC (Crohn's disease diagnosed within 4 years) %

Conventional step-up (steroids→AZA→IFX)	Step-down (IFX x3, with AZA)
2 yr	30	73	(43)
3-4 yr
No flare, no steroids, on demand IFX	about 65	about 20	(about 45)
No flare, no steroids, no TNFB	about 60	about 15	(about 45)
New or persistent fistulas	about 2	about 22	(about 20)

IFX: Infliximab; AZA: Azathioprine; TNFB: Tumor necrosis factor-α blockers.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823