Use of the tumor necrosis factor-blockers for Crohn's disease

doi:10.3748/wjg.v18.i35.4823

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Sep 21, 2012 (publication date) through Jul 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 31 Meta-analysis efficacy of 5-aminosalicylic acid/sulfasalazine to induce remission or to prevent relapse in Crohn's disease

	Induce remission (RR of not being in remission) on active therapy	Prevent relapse (RR of relapse)
CD	SASP (only 2 RCTs) 0.83 (95%CI: 0.69-1.00; trend)	SASP/5-ASA, ITT analysis, no benefit
	5-ASA 0.91 (95%CI: 0.77-1.06; not significant)	5-ASA, PP analysis: RR = 0.79 (95%CI: 0.66-0.95; NNT = 13 to prevent relapse)
UC	0.79 (95%CI: 0.73-0.85; NNT = 6)	0.65 (95%CI: 0.55-0.76; NNT = 4 to prevent relapse)

CD: Crohn's disease; ITT: Intention-to-treat; PP: Per protocol; SASP: Sulfasalazine; 5-ASA: 5-Aminosalicylic acid; CI: Confidence interval; UC: Ulcerative colitis; NNT: Needed to treat; RR: Relative risk; RCT: Randomized controlled trial.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823