Use of the tumor necrosis factor-blockers for Crohn's disease

doi:10.3748/wjg.v18.i35.4823

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Sep 21, 2012 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 30 Complete mucosal healing¹

	ADA	PL [ADA induction only (3 doses)]	TG (%)
ITT		PL
week 12	27%	13% (P = 0.056)	14
week 52	24%	0% (P < 0.001)	24
PP
week 12	28%	13% (P = 0.046)	15

¹Extend: Open-label adalimumab[182]. Of patients with CMH at week 12, 46% of ADA every other weeks had CMH at week 52 vs 0% CMH in those receiving only ADA induction. ITT: Intention-to-treat; PP: Per protocol; TG: Therapeutic gain; PL: Placebo; ADA: Adalimumab.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823