Use of the tumor necrosis factor-blockers for Crohn's disease

doi:10.3748/wjg.v18.i35.4823

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Sep 21, 2012 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 3 Comparison of in vitro properties of different tumor necrosis factor-α blockers in clinical practice for inflammatory bowel disease

Agent	Binds	Mediates		Increases proportion of apoptotic cells	Inhibits cytokine production	Effective in IBD patients
	TNF	CDC	ADCC
Infliximab	Yes	Yes	Yes	Yes	Yes	Yes
Etanercept	Yes	Yes	Yes	Yes	No	No
Adalimumab	Yes	Yes	Yes	Yes	Yes	Yes
Certolizumab pegol	Yes	No	No	No	Yes	Yes

TNF: Tumor necrosis factor; ADCC: Antibody-dependent cell-mediated cytotoxicity; CDC: Complement-dependent cytotoxicity; IBD: Inflammatory bowel disease.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823