Use of the tumor necrosis factor-blockers for Crohn's disease

doi:10.3748/wjg.v18.i35.4823

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Sep 21, 2012 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 27 Meta-analysis of efficacy and safety of biological therapies vs placebo in inducing remission in moderately to severely active ulcerative colitis[61]

Treatment	Outcome (RR of remission not being achieved)
IFX vs PL	RR = 0.72; 95%CI: 0.57-0.91
	NNT = 4 (95%CI: 3-8)
Adverse event
Any adverse event was no higher in IFX vs PL, and risk of serious adverse events was lower	RR of serious adverse event = 0.64; 95%CI: 0.41-1.00, P = 0.05
	NNH = 13 (95%CI: 8-50)

IFX: Infliximab; PL: Placebo; RR: Risk ratio; CI: Confidence interval; UC: Ulcerative colitis; NNT: Needed to treat.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823