Use of the tumor necrosis factor-blockers for Crohn's disease

doi:10.3748/wjg.v18.i35.4823

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Sep 21, 2012 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 19 Comparative efficacy of infliximab, adalimumab and certolizumab (%)

Induction	Response¹	Remission²		Therapeutic gain
		TNFBs	PL
AccentI	58	39	21	18
CHARM	58	46	17	29
Precise 2	64	48	29	19

¹Weeks 2 to 6;

²Weeks 26 to 30. Remission is often defined by the Crohn's disease activity index, but may also be defined using the Inflammatory Bowel Disease Questionnaire. PL: Placebo; TNFBs: Tumor necrosis factor-α blockers; CHARM: Crohn's trial of the fully human antibody adalimumab for remission maintenance.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823