Use of the tumor necrosis factor-blockers for Crohn's disease

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Sep 21, 2012 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4823-4854
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4823

Table 1 The general biological properties of tumor necrosis factor blockers in clinical practice

Pro- or anti-apoptotic effects¹

↑ Adhesion molecules on endothelial cells

↑ Epithelial permeability

↑ Antigen-stimulated B-cell proliferation and differentiation

IL-2R production¹

↑ IL-2 dependent production of IFN-γ

↑HLA-DR gene expression

¹Represent the data are increased. IFN-γ: Intracellular interferon-γ; IL: Interleukin.

Citation: Thomson AB, Gupta M, Freeman HJ. Use of the tumor necrosis factor-blockers for Crohn's disease. World J Gastroenterol 2012; 18(35): 4823-4854
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4823.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4823