Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers

doi:10.3748/wjg.v18.i34.4751

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2012; 18(34): 4751-4757
Published online Sep 14, 2012. doi: 10.3748/wjg.v18.i34.4751

Table 1 Clinical characteristics of patients and treatment modality of recurrent with primary liver cancer n (%)

	CK19^- HCC (n = 49)	CK19⁺ HCC (n = 21)	cHCC-CC (n = 22)	ICC(n = 19)	P value
Age (yr)					0.43
< 45	11 (22.4)	4 (19.0)	4 (18.2)	1 (5.3)
≥ 45	38 (77.6)	17 (81.0)	18 (81.8)	18 (94.7)
Gender					0.014^a
Male	41 (83.7)	14 (66.7)	18 (81.8)	9 (47.4)
Female	8 (16.3)	7 (33.3)	4 (18.2)	10 (52.6)
Underlying liver disease					0.004^a
None	0 (0.0)	0 (0.0)	3 (13.6)	12 (63.2)
HBV	38 (79.2)	18 (85.7)	17 (77.3)	2 (10.5)
HCV	4 (8.3)	0 (0.0)	0 (0.0)	0 (0.0)
Others	6 (12.5)	3 (14.3)	2 (9.1)	5 (26.3)
Cirrhosis					0.024^a
No	22 (44.9)	10 (47.6)	10 (45.5)	16 (84.2)
Yes	27 (55.1)	11 (52.4)	12 (54.5)	3 (15.8)
Tumor number					0.313
Single	41 (83.7)	17 (81.0)	16 (72.7)	18 (94.7)
Multiple	8 (16.3)	4 (19.0)	6 (27.3)	1 (5.3)
Satellite nodule					0.063
Absent	43 (87.8)	19 (90.5)	15 (68.2)	18 (94.7)
Present	6 (12.2)	2 (9.5)	7 (31.8)	1 (5.3)
Microvascular invasion					0.836
Absent	21 (42.9)	10 (47.6)	11 (55.0)	9 (47.4)
Present	28 (57.1)	11 (52.4)	9 (45.0)	10 (52.6)
Macrovascular invasion					0.119
Absent	45 (91.8)	17 (81.0)	19 (95.0)	14 (73.7)
Present	4 (8.2)	4 (19.0)	1 (5.0)	5 (26.3)
Lymph node metastasis					0.086
Absent	47 (95.9)	20 (95.5)	21 (95.5)	15 (78.9)
Present	2 (4.1)	1 (4.8)	1 (4.5)	4 (21.1)
Distant metastasis					0.521
Absent	46 (93.9)	21 (100)	21 (95.5)	17 (89.5)
Present	3 (6.1)	0 (0.0)	1 (4.5)	2 (10.5)
Differentiation					0.301
E1, E2 or well, moderate	15 (30.6)	7 (33.3)	9 (47.4)	9 (52.9)
E3, E4 or poorly	34 (69.4)	14 (66.7)	10 (52.6)	8 (47.1)
Treatment modality
Number of patience with recurrence	19/49 (38.8)	12/21 (57.1)	15/22 (68.2)	11/19 (57.9)
Conservative treatment	2/19 (10.5)	1/12 (8.3)	3/15 (20.0)	8/11 (72.7)
Transarterial chemoembolization	15/19 (78.9)	11/12 (91.7)	12/15 (80.0)	0/11 (0.0)
Systemic chemotherapy	0/19 (0.0)	0/12 (0.0)	0/15 (0.0)	2/11 (3.5)
Others	2/19 (10.5)	0/12 (0.0)	0/15 (0.0)	3/11 (5.3)

^aP < 0.05 among 4 groups. CK19^- HCC: Cytokeratin 19 negative hepatocellular carcinoma; CK19⁺ HCC: Cytokeratin 19 positive hepatocellular carcinoma; cHCC-CC: Combined hepatocellular carcinoma and cholangiocarcinoma; ICC: Intrahepatic cholangiocarcinoma; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Citation: Lee JI, Lee JW, Kim JM, Kim JK, Chung HJ, Kim YS. Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers. World J Gastroenterol 2012; 18(34): 4751-4757
URL: https://www.wjgnet.com/1007-9327/full/v18/i34/4751.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i34.4751