7-difluoromethoxyl-5,4’-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1

Figure 1 Inhibition of cell viability by genistein and genistein analogues. A: AGS cell line; B: SGC-7901 cell line. ^aP < 0.05 vs treatment with genistein; ^cP < 0.05 vs treatment with genistein or other genistein analogues. 1: Genistein (5,7,4'-trihydroxylisoflavone); 2: 7-difluoromethyl genistein; 4a: 7-difluoromethyl-5,4'-dimethyl genistein; 4b: 7-difluoromethyl-5,4'-diethyl genistein; 4c: 7-difluoromethyl-5,4’-di-n-propyl genistein; 4d: 7-difluoromethyl-5,4’-di-benzyl genistein; 4e: 7-difluoromethyl-5,4'-diheptyl genistein; 4f: 7-difluoromethyl-5,4'-di-n-octyl genistein; 4g: 7-difluoromethyl-5,4'-didecyl genistein; 4h: 7-difluoromethyl-5,4'-diisobutyl genistein.