Reduction of gastrointestinal motility by unilateral thyroparathyroidectomy plus subdiaphragmatic vagotomy in rats

Figure 6 Reduced contractile activity of the proximal colonic muscles in the thyroparatyroidectomy plus subdiaphragmatic vagotomy rats. Animals were sacrificed at 8 d after subdiaphragmatic vagotomy (VAX), and intact proximal colonic strips prepared from the age-matched normal and thyroparatyroidectomy (TPX) plus VAX rats were longitudinally or circularly mounted in a 10 mL organ bath. The contractile responses of colonic strips to acetylcholine (Ach) and N-nitro-L-arginine methyl ester (L-NAME) were measured by isometric force transducers. Figures show the representative tracings (A) and contractile responses to ACh (B) and L-NAME (C). Each point represents the mean ± SE of 7-9 rats. ^bP < 0.01 vs normal and sham-operated groups.