Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas

Table 1 Clinical characteristics, risk factors and overall genomic imbalances in 20 gastric adenocarcinomas

No.	ID	Sex/age (yr)	T/N/M stage	Tumor type	Histology grade (differentiated)	Tumor location	Smoke history	Drink history	Genomic size of total gain (Mb)	Genomic size of total loss (Mb)	Net imbalances (Mb) (%)2
1	T64	M/75	T3/N3/M0	Tubular	Poorly	Upper (CR), lower (AA)	Y	Y	290.7	147.3	+143.4 (4.8)
2	TW0800	M/65	T3/N3/M0	Tubular	Poorly	Upper (CR/GF), central (GB)	N	N	388.9	205.3	+183.6 (5.6)
3	T74	M/58	T3/N3/M0	Tubular	Poorly	Central (GB)	N	Y	290.1	412.3	-122.2 (4.1)
4	TW0784	M/75	T3/N1/M0	Tubular	Poorly	Upper (CR/GF)	N	N	3.4	0	+3.4 (0.1)
5	T66	M/50	T3/N2/M0	Tubular	Poorly	Lower (AA)	N	Y	34.2	0	+34.2 (1.1)
6	T78	F/59	T3/N1/M0	Tubular	Poorly	Lower (AA)	N	N	146.2	0	+107.4 (3.6)
7	T41	M/73	T3/N2/M0	Tubular	Poorly	Lower (AA/P)	Y	Y	7.2	0	+7.2 (0.2)
8	T47	F/52	T3/N1/M0	Tubular	Poorly	Lower (AA)	N	N	0.0	0.0	0.0 (0.0)
9	T38	F/53	T2/N1/M0	Tubular	Poorly	Lower (AA/P)	N	N	294.3	37.4	+256.9 (8.6)
10	TW0796	M/56	T3/N1/M0	Tubular	Poorly	Lower (AA/P)	Y	Y	224.4	11.9	+212.5 (7.1)
11	TW0807	M/54	T3/N0/M0	Tubular	Poorly	Lower (AA/P)	Y	Y	191.7	43.7	+148.0 (4.9)
12	TW0813	F/57	T3/N2/M0	Tubular1	Poorly	Lower (AA/P)	N	N	76.1	54.6	+21.5 (0.7)
13	T52	M/73	T3/N2/M0	Tubular	Moderately	Upper (CR/GF)	N	N	333.9	361.8	-27.9 (0.9)
14	TW0797	M/62	T3/N1/M0	Tubular	Moderately	Upper (CR/GF)	N	Y	161.1	0	+161.1 (5.4)
15	TW0782	M/53	T3/N2/M0	Tubular	Moderately	Upper (CR/GF)	Y	N	290.1	108.3	+181.8 (6.1)
16	TW0780	F/59	T2/N0/M0	Tubular	Moderately	Lower (AA/P)	N	N	4.1	4.16	-0.06 (0.0)
17	T75	M/69	T3/N2/M0	Tubular	Moderately	Lower (AA)	Y	Y	28	0	+28.0 (0.9)
18	T76	F/59	T3/N1/M0	Mucinous	Poorly	Upper (CR/GF)	Y	Y	99.1	0	+99.1 (3.3)
19	TW0789	M/64	T3/N1/M0	Mucinous	Poorly	Lower (AA/P)	N	N	504.5	167.6	+336.9 (11.2)
20	TW0774	F/76	T3/N3/M0	Mucinous	Poorly	Lower (AA/P)	N	N	41.4	90.4	-49.0 (1.6)

¹Signet ring cell;

²Percent of net imbalances calculated based on 3000 Mb of genome size. F: Female; M: Male; T: Tumor; N: Node; M: Metastasis ; CR: Cardiac region; GF: Gastric fundus; GB: Gastric body; AA: Antral area; P: Pylorus; Y: Yes; N: No.