Role of taxanes in pancreatic cancer

Table 2 Clinical trials of paclitaxel as single agent or in combination chemotherapy in pancreatic cancer

Trial	CT agent	Line CT	No. of patients	RR %	mPFS (mo)	mOS (mo)	Toxicity %
Whitehead et al[10]	PTX	I	45	CR 3 PR 5 SD 13	NR	5	Neutropenia + leukopenia 92 , anemia 23, thrombocytopenia 20, asthenia 23, nausea-vomiting 18, neuropathy 7
Saif et al[46]	GPM	I	56	CR 1.7 PR 3.5 SD 54.8	2.8	6.5	Neutropenia 40, asthenia 17.8, neuropathy 13.3
Löhr et al[48]	GEM GEM + ET 11 mg/mq GEM + ET 22 mg/mq GEM + ET 44 mg/mq	I	212	CR 0/0/0/0 PR 14/14/14/16 SD 30/46/51/35	2.7/4.1/4.6/4.4	6.8/8.1/8.7/9.3	Neutropenia 18/12/16/22, anemia 4/0/4/8, thrombocytopenia 2/8/16/14, nausea + vomiting 2/2/0/10
Von Hoff et al[50]	Nab-PTX + GEM	I	67	CR 4 PR 42 SD 18	7.9	12.2	Neutropenia 67, thrombocytopenia 23, asthenia 21, neuropathy 15
Hosein et al[51]	Nab-PTX	II	19	CR 0 PR 5.3 SD 31.6	1.6	7.3	Neutropenia 32, febrile neutropenia 11, anemia 11
Kim et al[52]	PTX + 5-FU	II	28	CR 0 PR 10 SD 20	2.51	7.6	Leukopenia 6, diarrhea 2, neuropathy 1

¹mTTP: Median time to progression; CT: Chemotherapy; RR: Response rate; mPFS: Median progression free survival; mOS: Median overall survival; PTX: Paclitaxel; NR; Not reported; GPM: Paclitaxel loaded polymeric micelle, ET: Paclitaxel embedded in cationic liposomes; Nab-PTX: Paclitaxel protein-bound particles; 5-FU: 5-fluorouracil.