Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis

Figure 2 Endoscopic images of the diverted segments of the colon treated with different protocols at 4 wk, before treatment, and at 8 wk, the peak of inflammation in this experimental model. Diversion colitis is characterized by the presence of a fragile mucosa, hyperemia, spontaneous bleeding, and increased number of vessels and mucous secretion (at 8 wk). Colonoscopic images were semi-quantitatively analyzed with an endoscopic score. Animals treated with either glutamine or butyrate showed significantly reduced colonoscopic scores compared to animals without any treatment at 8 and 12 wk. Significant differences are noted (n = 6 in each group).