Gene expression profiling and endothelin in acute experimental pancreatitis

Figure 5 Mechanical and thermal hypersensitivity. A: Rats with pancreatitis demonstrate fewer withdrawal events in response to mechanical stimuli at time points after treatment with BQ123 [endothelin (ET)-A receptor antagonist, 300 μmol/L] and BQ788 (ET-B receptor antagonist, 300 μmol/L). The response to BQ788 persisted for a shortened amount of time compared to the longer lasting to BQ123. Data is presented as actual number of events (n = 5); B: Endothelin-A receptor antagonist (BQ123) normalized secondary thermal hypersensitivity that was shortened after induction of pancreatitis. The effect persisted longer for BQ123 compared to shorter response to BQ788 antagonist (n = 5). PBS: Phosphate buffered saline; DBTC: Dibutyltin dichloride.