X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: A meta-analysis

Table 1 Characteristics of eligible studies included in this study

Ref.	Country (ethnicity)	Genotyping method	Cases/controls	Source of controls	Type of controls	Polymorphisms of XRCC1 gene
Tang et al[26]	China (Asian)	PCR–RFLP	150/15	Hospital	Age matched, male and healthy	Arg194Trp, Arg280His, Arg399Gln
Bo et al[30]	China (Asian)	PCR–RFLP	130/130	Hospital	Age matched and healthy	Arg194Trp
Zeng et al[29]	China (Asian)	TaqMan SNP Genotyping	545/515	Hospital	Age, sex and residence matched and without cancer	Arg194Trp, Arg280His, Arg399Gln
Kiran et al[22]	India (Asian)	PCR–RFLP	63/155	Hospital	HBsAg (-), anti-HCV (-), and without renal or hepatic disease	Arg194Trp, Arg280His, Arg399Gln
Wu et al[27]	China (Asian)	PCR–RFLP	100/60	Hospital	Age and sex matched, healthy and HBsAg (-)	Arg280His
Ren et al[25]	China (Asian)	PCR–RFLP	50/92	Hospital	Healthy and HBsAg (-)	Arg399Gln
Borentain et al[20]	France (Caucasian)	Sequencing	56/89	Population	Healthy and without chronic liver disease	Arg399Gln
Kirk et al[23]	Gambia (African)	PCR–RFLP	195/352	Hospital	Age and sex matched, normal α-fetoprotein levels, and without clinical evidence of liver disease	Arg399Gln
Long et al[24]	China (Asian)	PCR–RFLP	140/536	Hospital	Age, sex and ethnicity matched and without cancer	Arg399Gln
Han et al[21]	China (Asian)	PCR–RFLP	69/136	Population	Age, sex and residence matched	Arg399Gln
Yu et al[28]	China (Asian)	PCR–RFLP	577/389	Population	Age and sex matched, HBsAg (+), and without HCC	Arg399Gln

XRCC1: X-ray repair cross-complementing group 1; PCR–RFLP: Polymerase chain reaction-restriction fragment length polymorphism; SNP: Single nucleotide polymorphism; HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma.