Diabetes but not insulin is associated with higher colon cancer mortality

doi:10.3748/wjg.v18.i31.4182

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2012; 18(31): 4182-4190
Published online Aug 21, 2012. doi: 10.3748/wjg.v18.i31.4182

Table 1 Age/sex-specific mortality rates (per 100 000 person-years) for colon cancer in diabetic patients and their mortality rate ratios compared to the average mortality rates in the general population of Taiwan

Age (yr)	Men					Women
	n	N	PY	MR	MRR (95% CI)	n	N	PY	MR	MRR (95% CI)
Original diabetic cohort
Followed from enrollment to the end of 2006
25-54	76	42107	363948.2	20.88	5.69 (4.65, 6.96)^a	43	43749	399556.9	10.76	3.05 (2.29, 4.06)^a
55-64	158	28867	225706.1	70.00	2.75 (2.36, 3.21)^a	146	37317	314033.6	46.49	2.67 (2.27, 3.14)^a
65-74	265	30704	211811.1	125.11	2.01 (1.78, 2.27)^a	238	35194	258155.6	92.19	2.09 (1.84, 2.38)^a
≥ 75	142	11669	59761.6	237.61	1.65 (1.40, 1.95)^a	146	15313	83905.5	174.01	1.46 (1.24, 1.72)^a
Followed from enrollment to the end of 2000
25-54	23	42107	143238.6	16.06	4.38 (3.00, 6.37)^a	16	43749	153584.7	10.42	2.95 (1.84, 4.71)^a
55-64	52	28867	96078	54.12	2.12 (1.62, 2.78)^a	55	37317	129321.2	42.53	2.44 (1.88, 3.17)^a
65-74	112	30704	94488.8	118.53	1.90 (1.58, 2.29)^a	91	35194	113687.6	80.04	1.81 (1.48, 2.23)^a
≥ 75	70	11669	30353.6	230.61	1.60 (1.27, 2.03)^a	75	15313	42092.9	178.18	1.49 (1.19, 1.87)^a
Followed from 2001 to the end of 2006
25-54	30	32626	186021.3	16.13	4.39 (3.16, 6.11)^a	22	34400	201514.2	10.92	3.09 (2.07, 4.60)^a
55-64	68	22743	122446.4	55.53	2.18 (1.72, 2.76)^a	52	29880	167205.9	31.10	1.79 (1.36, 2.34)^a
65-74	172	26548	133463.8	128.87	2.07 (1.78, 2.40)^a	131	33591	176023.3	74.42	1.69 (1.42, 2.00)^a
≥ 75	114	13653	59608.3	191.25	1.33 (1.11, 1.60)^a	131	17808	79994.6	163.76	1.37 (1.16, 1.63)^a
Sub-cohort diabetic patients
Diabetes of any duration at enrollment
25-54	25	13837	100793.2	24.80	6.76 (4.81, 9.50)^a	16	12768	95960.8	16.67	4.72 (3.02, 7.37)^a
55-64	62	12454	84551.8	73.33	2.88 (2.26, 3.66)^a	53	16717	118278.5	44.81	2.57 (1.98, 3.35)^a
65-74	99	12395	76349.6	129.67	2.08 (1.71, 2.53)^a	86	15029	96058.4	89.53	2.03 (1.64, 2.50)^a
≥ 75	42	3574	17710.4	237.15	1.65 (1.22, 2.23)^a	43	4891	25384.8	169.39	1.42 (1.05, 1.91)^a
Diabetes duration < 10 yr at enrollment
25-54	15	11631	86016.8	17.44	4.75 (3.00, 7.53)^a	12	10389	78983.7	15.19	4.30 (2.56, 7.23)^a
55-64	42	8892	61949.1	67.80	2.66 (1.99, 3.57)^a	37	11636	84435.4	43.82	2.52 (1.84, 3.45)^a
65-74	62	7887	49825.0	124.44	2.00 (1.56, 2.55)^a	47	9246	61226.8	76.76	1.74 (1.31, 2.31)^a
≥ 75	29	2138	10946.7	264.92	1.84 (1.29, 2.64)^a	23	2814	15302.6	150.30	1.26 (0.84, 1.90)
Diabetes duration ≥ 10 yr at enrollment
25-54	10	2206	14773	67.69	18.44 (11.81, 28.80)^a	4	2379	16988.5	23.55	6.66 (2.85, 15.56)^a
55-64	20	3562	22608.3	88.46	3.47 (2.30, 5.25)^a	16	5081	33862.5	47.25	2.71 (1.69, 4.35)^a
65-74	37	4508	26541.7	139.40	2.24 (1.63, 3.07)^a	39	5783	34845.7	111.92	2.54 (1.87, 3.44)^a
≥ 75	13	1436	6785.4	191.59	1.33 (0.77, 2.29)	20	2077	10103.5	197.95	1.66 (1.07, 2.56)^a
Sub-cohort type 2 diabetic patients
Diabetes of any duration at enrollment
25-54	23	13239	96635.9	23.80	6.49 (4.54, 9.26)^a	16	12260	92076.3	17.38	4.92 (3.16, 7.66)^a
55-64	60	12082	82183.2	73.01	2.87 (2.24, 3.66)^a	51	16288	115494.5	44.16	2.54 (1.94, 3.32)^a
65-74	92	12051	74413.3	123.63	1.98 (1.62, 2.43)^a	83	14570	93223.1	89.03	2.02 (1.63, 2.50)^a
≥ 75	39	3448	17171.3	227.12	1.58 (1.16, 2.16)^a	43	4756	24716.7	173.97	1.46 (1.08, 1.97)^a
Diabetes duration < 10 yr at enrollment
25-54	14	11248	83333.9	16.80	4.58 (2.84, 7.38)^a	12	10082	76622.8	15.66	4.43 (2.64, 7.44)^a
55-64	40	8730	60901.6	65.68	2.58 (1.91, 3.48)^a	36	11453	83223.4	43.26	2.48 (1.81, 3.42)^a
65-74	59	7742	48999.2	120.41	1.93 (1.50, 2.49)^a	46	9068	60169.4	76.45	1.73 (1.30, 2.31)^a
≥ 75	27	2088	10708.6	252.13	1.75 (1.21, 2.55)^a	23	2760	15063.9	152.68	1.28 (0.85, 1.93)
Diabetes duration ≥ 10 yr at enrollment
25-54	9	1991	13298.7	67.68	18.44 (11.53, 29.50)^a	4	2178	15465.0	25.86	7.32 (3.17, 16.88)^a
55-64	20	3352	21284.3	93.97	3.69 (2.45, 5.56)^a	15	4835	32290.5	46.45	2.67 (1.64, 4.35)^a
65-74	33	4309	25428.1	129.78	2.08 (1.49, 2.91)^a	37	5502	33067.7	111.89	2.53 (1.85, 3.47)^a
≥ 75	12	1360	6484.3	185.06	1.29 (0.73, 2.26)	20	1996	9674.1	206.74	1.73 (1.12, 2.67)^a

^aP < 0.05 vs general population. PY: Person-years; MR: Mortality rate; MRR: Mortality rate ratio; CI: Confidence interval; n: Case number of colon cancer; N: Case number observed.

Citation: Tseng CH. Diabetes but not insulin is associated with higher colon cancer mortality. World J Gastroenterol 2012; 18(31): 4182-4190
URL: https://www.wjgnet.com/1007-9327/full/v18/i31/4182.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i31.4182