Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer

Table 3 Univariate and multivariate analysis of overall survival in signet ring cell carcinoma (n = 79)

Characteristics	Groups	HR (95% CI)	P value
Univariate analysis
Age (yr)	> 60 vs ≤ 60	1.11 (0.52-2.37)	0.785
Gender	F vs M	1.08 (0.56-2.07)	0.817
PKM2	Positive vs negative	2.13 (1.02-4.44)	0.042
T stage	T4 vs T1/2/3	6.25 (3.03-12.85)	< 0.001
N stage	N3 vs N0/1/2	5.70 (2.90-11.22)	< 0.001
Stage	III vsI/II	6.84 (2.83-16.53)	< 0.001
Multivariate analysis
PKM2	Positive vs negative	2.12 (1.02-4.42)	0.044
Stage	III vsI/II	6.84 (2.83-16.55)	< 0.001

HR: Hazard ratio; PKM2: The M2 isoform of pyruvate kinase; 95% CI: 95% confidence interval; F: Female; M: Male; T: Tumor; N: Node.