Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis

Table 7 Head-to-head comparison of sensitivity for adenoma of faecal pyruvate kinase isoenzyme type M2 and guaiac-based faecal occult blood test n (%)

Reference	Adenoma < 1 cmøM2-PK	Adenoma < 1 cmøgFOBT	Adenoma > 1 cmøM2-PK	Adenoma > 1 cmøgFOBT	Adenoma w/oøM2-PK	Adenoma w/oøgFOBT
Naumann et al[45], 2004	11 (27.3)	11 (18.2)	13 (61.5)	13 (30.8)
Vogel et al[44], 2005					21 (48)	21 (9)
Shastri et al[7], 2006	21 (28.6)	21 (9.5)	10 (20.0)	10 (30.0)
Koss et al[8], 2008	5 (20.0)	5 (0.0)	5 (60.0)	5 (20.0)
Sum	37	37	28	28	21	21
mean ± SD	25 ± 5	9 ± 9	47 ± 24	27 ± 6

n: Number of samples tested; %: Sensitivity; w/o ø: Without measurement of diameter; ø: Diameter; gFOBT: Guaiac-based faecal occult blood test; M2-PK: Pyruvate kinase isoenzyme type M2.