Effects of Lactobacillus plantarum on gut barrier function in experimental obstructive jaundice

doi:10.3748/wjg.v18.i30.3977

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2012; 18(30): 3977-3991
Published online Aug 14, 2012. doi: 10.3748/wjg.v18.i30.3977

Table 4 Expression (mRNA) ratio (studied genes/β-actin) for tight junction and protein kinase C in terminal ileum tissues of each experimental group (mean ± SD)

Genes	Group I	Group II	Group III	Group IV	Group V
Occludin	2.5458 ± 0.2260	0.4881 ± 0.0426^a	0.9792 ± 0.2066	1.4902 ± 0.0720^c	1.8976 ± 0.1049
ZO-1	7.2420 ± 0.4025	0.9541 ± 0.1629^a	1.4064 ± 0.1632	2.8843 ± 0.1641^c	4.0727 ± 0.2059
Claudin-1	1.9751 ± 0.0615	0.0546 ± 0.0336^a	0.4741 ± 0.0897	0.9092 ± 0.1295^c	1.4793 ± 0.2119
Claudin-4	42.8680 ± 7.5291	0.3546 ± 0.0916^a	5.3245 ± 1.1801	8.7719 ± 1.4659^c	15.9592 ± 2.8815
JAM-A	3..3259 ± 0.3704	0.4712 ± 0.1107^a	0.9456 ± 0.1101	1.6270 ± 0.2153^c	2.1006 ± 0.1534
PKC	6.6958 ± 0.9349	1.7959 ± 0.2992^a	2.8281 ± 0.3287	3.7178 ± 0.5110^c	4.7235 ± 0.4958

^aP < 0.05 vs Group III;

^cP < 0.05 vs Group V. Group I: Sham-operation; Group II: Bile duct ligation (BDL); Group III: BDL + L. plantarum; Group IV: BDL + internal biliary drainage (IBD); Group V: BDL + IBD + L. plantarum. JAM-A: Junction adhesion molecule-A; PKC: Protein kinase C.

Citation: Zhou YK, Qin HL, Zhang M, Shen TY, Chen HQ, Ma YL, Chu ZX, Zhang P, Liu ZH. Effects of Lactobacillus plantarum on gut barrier function in experimental obstructive jaundice. World J Gastroenterol 2012; 18(30): 3977-3991
URL: https://www.wjgnet.com/1007-9327/full/v18/i30/3977.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i30.3977