1H NMR-based serum metabolic profiling in compensated and decompensated cirrhosis

Table 1 Clinical and biochemical characteristics of the cirrhotic patients and controls

		Liver cirrhosis
Parameter	Control (n = 30)	Compensated LC (n = 30)	Decompensated LC (n = 30)
Age (yr)	48.8 ± 10.5	56.3 ± 12.9	58.7 ± 14.5
Gender (M:F)	12:18	14:16	15:15
ALT (U/L)	20.4 ± 10.2	110.4 ± 20.2a	85.4 ± 32.6a
AST (U/L)	15.3 ± 11.6	187.5 ± 100.5a	142.4 ± 52.9a
TP (g/L)	65.4 ± 5.6	61.5 ± 10.2	60.4 ± 5.7a
ALB (g/L)	50.4 ± 10.2	48.6 ± 6.9	35.8 ± 11.2ab
T-BIL (μmol/L)	11.4 ± 3.6	35.8 ± 30.9a	45.6 ± 20.2a
D-BIL (μmol/L)	5.4 ± 1.2	15.4 ± 8.3a	23.4 ± 10.2ab
GLU (mmol/L)	5.31 ± 1.6	5.48 ± 1.23	5.47 ± 0.98
CRE (μmol/L)	113.6 ± 56.3	140.3 ± 50.8	152.6 ± 34.2a
INR	1.0 ± 0.05	1.1 ± 0.06	1.2 ± 0.12
MELD score	-	12.7 ± 3.5	14.2 ± 6.3

^aP < 0.05 vs control,

^bP < 0.05 vs compensated group. Data are the number of patients or the mean ± SD.