Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

Table 4 Unadjusted and adjusted associations between nonalcoholic fatty liver disease and age, menopause status, hormone replacement therapy, metabolic syndrome and weight gain in 1247 women

	Unadjusted odds ratio (95% CI)	P values	Adjusted odds ratio (95% CI)	P values
Age	1.05 (1.02-1.08)	0.001	1.06 (1.02-1.1)	0.004
Menopause	2.26 (0.76-6.69)	0.14	1.22 (0.38-3.99)	0.74
Postmenopausal state	1.8 (1.03-3.15)	0.039	0.72 (0.31-1.66)	0.44
Active hormone replacement therapy	1.56 (0.76-3.19)	0.22	1.32 (0.6-2.88)	0.49
Presence of metabolic syndrome at baseline	9.89 (4.67-20.94)	< 0.001	11.7 (5.02-27.25)	< 0.001
Weight gain	1.50 (1.30-1.74)	< 0.001	1.63 (1.39-1.9)	< 0.001

We calculated the odds ratio of each factor for nonalcoholic fatty liver disease in a univariate logistic regression model. The columns to the left indicate unadjusted odds ratio [95% confidence interval (CI)]. We selected all parameters as cofactors in a multivariate logistic regression model. The columns to the right indicate adjusted odds ratio (95% CI).