Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease

Table 5 Complications defined in ulcerative colitis studies

Study	Study Endpoints	Infectious	Medical	Surgical	Pouch
Selvasekar[25]	Post-operative pouch specific and infectious complications	Pouch complications plus; wound infections			Anastomotic leak; pelvic abscess
Schluender[26]	30 d post-operative surgical and medical complications	Not defined	Major: pneumonia, DVT, pancreatitis, ARF, CVA; minor: dehydration, thrombophlebitis, pyoderma gangrenosum, urinary retention	Major: SBO, abscess, bleeding, leak; minor: wound infection, ileus, bleeding
Mor[27]	Early (30 d) and late post-operative complications	Early: pelvic sepsis, bleeding, thrombosis, ileus; Late: pouchitis, SBO, stricture
Ferrante[28]	30 d post-operative complications	Surgical infections: pouch complications plus wound infection; non surgical: UTI and respiratory infections			Anastomotic leak; pelvic abscess
Kunitake[29] (combined study)	Post-operative cumulative complications	Infections, hypomotility, thrombotic, cardiac complications, hepato-renal complications, anastomotic leak, bleeding and death

DVT: Deep vein thrombosis; ARF: Acute renal failure; CVA: Cerebrovascular accident; SBO: Small bowel obstruction; UTI: Urinary tract infections.