Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease

Table 2 Complications defined in crohn’s disease

Study	Study endpoints	Infectious	Non-infectious	Major	Minor
Marchal[22]	Early (10 d) and late (3 mo) complications	Catheter sepsis, wound, upper respiratory, Diarrhea,yeast		Sepsis, leak, peritonitis, abscess, wound failure, severe anemia, bulbar ulcer bleeding	Hematoma, fever, delayed transit, mild infection, intestinal obstruction
Colombel[23]	Early (30 d) septic and non septic complications	Wound sepsis, leak, abscess, fistula, sepsis, pneumonia, bacteremia, urosepsis	CD recurrence, small bowel obstruction, GI bleeding, thromboembolism
Appau[24]	30 d post-operative complications	Wound infection, sepsis, intra abdominal abscess, 30 d mortality, readmission rate, anastomotic leak and wound complications
Kunitake[29] (combined study)	Post-operative cumulative complications	Infections, hypomotility, thrombotic, cardiac complications, hepato-renal complications, anastomotic leak, bleeding and death

CD: Crohn’s disease; GI: Gastrointestinal.