Moro orange juice prevents fatty liver in mice

Figure 4 Effects of Moro juice on liver lipid homeostasis. Gene expression of (A) peroxisome proliferator-activated receptor (PPAR)-α and (B) acyl-CoA oxidase (AOX) was significantly increased in mice fed high-fat diet (HFD) + Moro, whereas gene expression of (C) liver X receptor (LXR)-α, (D) fatty acid synthase (FAS) and (E) hydroxy methylglutaryl (HMG)-CoA reductase was markedly reduced by orange juice; Liver glycerol-3-phosphate acyltransferase 1 (GPAT1) was increased in mice fed HFD + water and was restored to control levels in mice drinking Moro juice (F). ^aP < 0.05 vs standard diet (SD) + water, ^cP < 0.05 vs HFD + water.