Differential roles of EPS8 in carcinogenesis: Loss of protein expression in a subset of colorectal carcinoma and adenoma

doi:10.3748/wjg.v18.i29.3896

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2012; 18(29): 3896-3903
Published online Aug 7, 2012. doi: 10.3748/wjg.v18.i29.3896

Table 2 Analysis of epidermal growth factor receptor pathway substrate 8 gene status and protein expression in uncultured tumor specimens n (%)

	Total number	Membranousβ-catenin	LOH¹	EPS8 protein loss	EPS8 mutation²	Methylation³
Sporadic carcinomas	22	10/22 (45)	7/19 (37)	11/22 (50)	0/11	0/7
Sporadic adenomas	15	4/10 (40)	6/15 (40)	4/14 (29)	0/4	ND
FCC-X	21	11/18 (61)	7/17 (41)	4/15 (27)	ND	ND
Total	58		20/51 (39)	19/51 (37)	0/15	0/7

¹Based on informative (i.e., constitutionally heterozygous) cases;

²Cases with protein loss by immunohistochemistry and/or presence of loss of heterozygosity (LOH) were selected for this analysis;

³Cases were selected on the basis of immunohistochemical protein loss without LOH. ND: Not done; FCC-X: Familial colon cancer type X; EPS8: Epidermal growth factor receptor pathway substrate 8.

Citation: Abdel-Rahman WM, Ruosaari S, Knuutila S, Peltomäki P. Differential roles of EPS8 in carcinogenesis: Loss of protein expression in a subset of colorectal carcinoma and adenoma. World J Gastroenterol 2012; 18(29): 3896-3903
URL: https://www.wjgnet.com/1007-9327/full/v18/i29/3896.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i29.3896