Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

Table 2 Candidate gene list (in bold) and 50 predicted genes by systems biology

Symbol	Description	Score
HNF4A	Hepatocyte nuclear factor 4, alpha [source: HGNC symbol; Acc: 5024]	66.77
IDH2	Isocitrate dehydrogenase 2 (NADP+), mitochondrial [source: HGNC symbol; Acc: 5383]	62.04
IDH1	Isocitrate dehydrogenase 1 (NADP+), soluble [source: HGNC symbol; Acc: 5382]	61.96
GPT	Glutamic-pyruvate transaminase (alanine aminotransferase) [source: HGNC symbol; Acc: 4552]	58.97
GOT1	Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) [source: HGNC symbol; Acc: 4432]	54.78
GOT2	Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) [source: HGNC symbol; Acc: 4433]	54.48
IDH3A	Isocitrate dehydrogenase 3 (NAD+) alpha [source: HGNC symbol; Acc: 5384]	2.68
IDH3G	Isocitrate dehydrogenase 3 (NAD+) gamma [source: HGNC symbol; Acc: 5386]	2.6
IDH3B	Isocitrate dehydrogenase 3 (NAD+) beta [source: HGNC symbol; Acc: 5385]	2.56
ALAS1	Aminolevulinate, delta-, synthase 1 [source: HGNC symbol; Acc: 396]	1.57
GOT1L1	Glutamic-oxaloacetic transaminase 1-like 1 [source: HGNC symbol; Acc: 28487]	1.35
ACCSL	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like [source: HGNC symbol; Acc: 34391]	1.14
GPT2	Glutamic pyruvate transaminase (alanine aminotransferase) 2 [source: HGNC symbol; Acc: 18062]	1.03
ACCS	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) [source: HGNC symbol; Acc: 23989]	0.98
TAT	Tyrosine aminotransferase [source: HGNC symbol; Acc: 11573]	0.93
AADAT	Aminoadipate aminotransferase [source: HGNC symbol; Acc: 17929]	0.88
CCBL1	Cysteine conjugate-beta lyase, cytoplasmic [source: HGNC symbol; Acc: 1564]	0.87
CCBL2	Cysteine conjugate-beta lyase 2 [source: HGNC symbol; Acc: 33238]	0.83
SPTLC3	Serine palmitoyltransferase, long chain base subunit 3 [source: HGNC symbol; Acc: 16253]	0.82
ALAS2	Aminolevulinate, delta-, synthase 2 [source: HGNC symbol; Acc: 397]	0.8
SPTLC2	Serine palmitoyltransferase, long chain base subunit 2 [source: HGNC symbol; Acc: 11278]	0.79
SPTLC1	Serine palmitoyltransferase, long chain base subunit 1 [source: HGNC symbol; Acc: 11277]	0.75
PC	Pyruvate carboxylase [source: HGNC symbol; Acc: 8636]	0.69
SLC2A4	Solute carrier family 2 (facilitated glucose transporter), member 4 [source: HGNC symbol; Acc: 11009]	0.69
GCAT	Glycine C-acetyltransferase [source: HGNC symbol; Acc: 4188]	0.66
RCAN1	Regulator of calcineurin 1 [source: HGNC symbol; Acc: 3040]	0.56
SEPSECS	Sep (O-phosphoserine) tRNA: Sec (selenocysteine) tRNA synthase [source: HGNC symbol; Acc: 30605]	0.56
GLUD1	Glutamate dehydrogenase 1 [source: HGNC symbol; Acc: 4335]	0.55
SHMT2	Serine hydroxymethyltransferase 2 (mitochondrial) [source: HGNC symbol; Acc: 10852]	0.54
CTH	Cystathionase (cystathionine gamma-lyase) [source: HGNC symbol; Acc: 2501]	0.52
AGXT2L2	Alanine-glyoxylate aminotransferase 2-like 2 [source: HGNC symbol; Acc: 28249]	0.49
RCAN2	Regulator of calcineurin 2 [source: HGNC symbol; Acc: 3041]	0.49
AGXT	Alanine-glyoxylate aminotransferase [source: HGNC symbol; Acc: 341]	0.48
GLDC	Glycine dehydrogenase (decarboxylating) [source: HGNC symbol; Acc: 4313]	0.48
GADL1	Glutamate decarboxylase-like 1 [source: HGNC symbol; Acc: 27949]	0.47
PDXDC1	Pyridoxal-dependent decarboxylase domain containing 1 [source: HGNC symbol; Acc: 28995]	0.45
AGXT2	Alanine--glyoxylate aminotransferase 2 [source: HGNC symbol; Acc: 14412]	0.45
GAD2	Glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa) [source: HGNC symbol; Acc: 4093]	0.43
SCLY	Selenocysteine lyase [source: HGNC symbol; Acc: 18161]	0.43
AGXT2L1	Alanine-glyoxylate aminotransferase 2-like 1 [source: HGNC symbol; Acc: 14404]	0.42
ABAT	4-aminobutyrate aminotransferase [source: HGNC symbol; Acc: 23]	0.42
DDC	Dopa decarboxylase (aromatic L-amino acid decarboxylase) [source: HGNC symbol; Acc: 2719]	0.42
KYNU	Kynureninase [source: HGNC symbol; Acc: 6469]	0.41
OAT	Ornithine aminotransferase [source: HGNC symbol; Acc: 8091]	0.4
SHMT1	Serine hydroxymethyltransferase 1 (soluble) [source: HGNC symbol; Acc: 10850]	0.4
PSAT1	Phosphoserine aminotransferase 1 [source: HGNC symbol; Acc: 19129]	0.39
GAD1	Glutamate decarboxylase 1 (brain, 67 kDa) [source: HGNC symbol; Acc: 4092]	0.38
CSAD	Cysteine sulfinic acid decarboxylase [source: HGNC symbol; Acc: 18966]	0.38
NFS1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae) [source: HGNC symbol; Acc: 15910]	0.38
ACO1	Aconitase 1, soluble [source: HGNC symbol; Acc: 117]	0.37
SGPL1	Sphingosine-1-phosphate lyase 1 [source: HGNC symbol; Acc: 10817]	0.36
HDC	Histidine decarboxylase [source: HGNC symbol; Acc: 4855]	0.36
MOCOS	Molybdenum cofactor sulfurase [source: HGNC symbol; Acc: 18234]	0.31
ZNHIT3	Zinc finger, HIT-type containing 3 [source: HGNC symbol; Acc: 12309]	0.3
COQ9	Coenzyme Q9 homolog (S. cerevisiae) [source: HGNC symbol; Acc: 25302]	0.3
ESRRA	Estrogen-related receptor alpha [source: HGNC symbol; Acc: 3471]	0.3

IDH: Isocitrate dehydrogenases; GPT: Glutamate pyruvate transaminase; GOT: Glutamate oxaloacetate transaminase.