Evaluation of a novel hybrid bioartificial liver based on a multi-layer flat-plate bioreactor

Table 1 Comparison of biochemical index between different groups in different time points

Groups	Time points	ALT	AST	LDH	TBIL	ALB	Ammonia	PT
Control (n = 8)
	Before modeling	64 ± 22.67	44.87 ± 11.6	210.14 ± 48.32	1.67 ± 0.57	30 ± 5	46.5 ± 11.98	8.4 ± 1.7
	After modeling	485.28 ± 140.2	651.35 ± 125.9	694.14 ± 232.8	28.45 ± 9.8	26.6 ± 5	62.25 ± 21.56	16.4 ± 5.2
	1 d after treatment	2438.64 ± 720.3	3201.9 ± 903	2433 ± 838.47	49 ± 15.77	24.8 ± 6.5	98.67 ± 21.7	28.67 ± 5.71
	3 d after treatment	860 ± 237.96	230.37 ± 92.37	867.25 ± 86.57	56.1 ± 5.3	22.3 ± 3.6	66.5 ± 8.54	24.83 ± 2.55
	5 d after treatment	144.6 ± 55.4	172.9 ± 36.57	639 ± 117.88	24.2 ± 6.45	21.4 ± 3.8	39.3 ± 9.5	10.5 ± 4.1
Bioartificial liver system (n = 8)
	Before modeling	51.78 ± 13.1	58.77 ± 13.4	285.5 ± 83.18	1.1 ± 0.4	29.42 ± 2.48	50.28 ± 14.28	8.2 ± 1.43
	After modeling	439.7 ± 180.98	811.7 ± 209.85	438.5 ± 138.2	18.12 ± 4.85	24.46 ± 1.97	55.5 ± 15.4	13.5 ± 4.1
	1 d after treatment	1511.54 ± 183.4	1472.46 ± 365	463 ± 76	25.92 ± 6.2	24.76 ± 4.46	46.4 ± 18.1	18.47 ± 4.41
	3 d after treatment	331.8 ± 31	51.2 ± 15.1	278.8 ± 67.2	28.84 ± 6.23	25.44 ± 3.52	38.2 ± 10.2	15.2 ± 7.6
	5 d after treatment	86.2 ± 24.5	46.3 ± 10.54	311.5 ± 84.35	12.47 ± 3.62	25.24 ± 1.93	34 ± 9.46	8.8 ± 2.7
Non-bioartificial liver system (n = 8)
	Before modeling	43.11 ± 19.44	41.77 ± 14.32	216.87 ± 46.2	2.44 ± 1	29.35 ± 3.08	50.25 ± 17.07	7.67 ± 0.315
	After modeling	447.5 ± 99.44	660.15 ± 152.13	536 ± 110	24.65 ± 2.57	24.36 ± 5.56	60.25 ± 15.12	14.6 ± 2.17
	1 d after treatment	1164.5 ± 332.5	1531.31 ± 294.96	485.5 ± 119.41	28.07 ± 9	23.61 ± 3.77	46 ± 13.6	21.71 ± 3.4
	3 d after treatment	286.2 ± 99.8	190.62 ± 30.9	379.8 ± 67.36	7.21 ± 3.6	23.94 ± 2.13	42.6 ± 8.17	19.48 ± 3.19
	5 d after treatment	89.15 ± 5.32	85.9 ± 11.98	530.25 ± 136.55	3.77 ± 1.83	23.92 ± 0.82	39.5 ± 7.59	7.95 ± 0.64
Hybrid bioartificial liver system (n = 8)
	Before modeling	56.5 ± 12.62	45.9 ± 10.56	233.25 ± 39	1.71 ± 0.28	29.4 ± 2.6	51.5 ± 8.94	7.62 ± 0.47
	After modeling	459.05 ± 80.57	681.95 ± 101	520.75 ± 101.22	18.8 ± 3.49	25.8 ± 3.2	54.37 ± 6.86	13.67 ± 2.66
	1 d after treatment	655.45 ± 97	1010.67 ± 118.95	301.12 ± 69.26	20.35 ± 2.68	28 ± 1.7	37.75 ± 6.09	15.5 ± 1.56
	3 d after treatment	117.97 ± 30.61	44.52 ± 9.7	222.5 ± 53.19	4.44 ± 1.02	28.3 ± 1.4	173.7 ± 8	8.36 ± 0.99
	5 d after treatment	55 ± 10.73	39.81 ± 8.72	334.25 ± 76.99	2.19 ± 0.55	27.7 ± 1.7	17.75 ± 3.77	8.3 ± 1.22

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LDH: Lactate dehydrogenase; TBIL: Total bilirubin; ALB: Albumin; PT: Prothrombin time.