Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases

Table 3 Immunohistochemical features of 24 cases of intraductal neoplasm of the intrahepatic bile duct

	Malignantn (16.67%)	Borderline n (3.12%)/adenoma n (5.21%)
MUC11
3+ (38%)	9 (56)	0
2+ (0%)	0	0
1+/- (62%)	7 (44)	8 (100)
MUC2
3+ (13%)	1 (6)	2 (25)
2+ (4%)	1 (6)	0
1+/- (83%)	14 (88)	6 (75)
MUC5AC
3+ (46%)	7 (44)	4 (50)
2+ (12%)	2 (12)	1 (13)
1+/- (42%)	7 (44)	3 (37)
MUC6
3+ (46%)	4 (25)	5 (63)
2+ (12%)	4 (25)	1 (22)
1+/- (44%)	8 (50)	2 (25)
Proliferation
Ki-67 (LI, %, mean ± SD)2	22.2 ± 15.5	7.5 ± 6.3
Genetic status
TP53 overexpression	0	0
β-catenin nuclear expression (17%)3	2 (13)	0

¹MUC1 expression was exhibited only in the malignant group (P = 0.0095);

² Ki-67 was significantly higher in malignant cases than in borderline/adenoma patients (P < 0.01);

³β-catenin expression was observed only in the cases with MUC1 expression. LI: Labeling index.