Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

Table 2 Comparison of clinicopathologic findings between the high microsatellite instability and non-high microsatellite instability early gastric cancer groups n (%)

	MSI-HEGC(n = 73)	Non-MSI-H EGC (n = 146)	P value
Patients characteristics
Sex			0.001
Male	37 (50.7)	108 (74.0)
Female	36 (49.3)	38 (26.0)
Age (yr)	63.4 ± 10.4	56.8 ± 11.1	< 0.001
Pathologic findings
Size (mm)	22.4 ± 15.7	26.5 ± 13.0	0.055
Depth of invasion
Mucosa	27 (37.0)	71 (48.6)	0.102
Submucosa	46 (63.0)	75 (51.4)
Histologic differentiation			0.003
(by WHO classification)
Well differentiated tubular	24 (32.9)	32 (21.9)
Moderately differentiated tubular	30 (41.1)	48 (32.9)
Poorly differentiated tubular	6 (8.2)	29 (19.9)
Signet ring cell	8 (11.0)	43 (24.0)
Mucinous	5 (6.8)	2 (1.4)
Lauren classification			0.017
Intestinal	61 (83.6)	100 (68.5)
Diffuse	12 (16.4)	46 (31.5)
Mucinous component	7 (9.6)	3 (2.1)	0.017
No signet ring cell component	60 (90.4)	116 (79.5)	0.041
Co-existing underlying adenoma	29 (39.7)	29 (19.9)	0.002
Lymphovascular invasion	17 (23.3)	22 (15.1)	0.134
Lymph node metastasis	12 (16.4)	14 (9.6)	0.14
Lymphoid stromal reaction			0.002
Absent-to-mild	49 (74.2)	91 (91.9)
Moderate-to-severe	17 (25.8)	8 (8.1)
Synchronous lesion			0.018
Early gastric cancer	7 (9.6)	5 (4.8)	0.11
Adenoma	7 (9.6)	7 (3.4)	0.163

MSI-H: High microsatellite instability; EGC: Early gastric cancer; WHO: World Health Organization.