Significance of regenerating islet-derived type IV gene expression in gastroenterological cancers

doi:10.3748/wjg.v18.i27.3502

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Jul 21, 2012 (publication date) through Aug 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2012; 18(27): 3502-3510
Published online Jul 21, 2012. doi: 10.3748/wjg.v18.i27.3502

Table 4 Articles reporting regenerating islet-derived type IV-targetted therapy

Author	Year	Method/type of cancer	Result
Bishunpuri et al[53]	2006	Transfection of rhR4/colorectal	Increase in pEGFR and pAkt
Takehara et al[20]	2006	Transfection of rhR4 and siRNA/pancreatic	Significant reduction in viable cells andincrease in pAkt
Legoffic et al[72]	2009	RegIV antibody injection/pancreatic	Significant reductions in Akt, Bcl-2 and Bcl-xL

rhR4: Recombinant human regenerating islet-derived type IV; RegIV: Human regenerating islet-derived type IV; siRNA: Small interfering RNA; pEGFR: Phosphorylated epidermal growth factor receptor; pAkt: Phosphorylated protein kinase B; Akt: Protein kinase B; Bcl-2: B-cell lymphoma 2; Bcl-xL: B-cell lymphoma-extra large.

Citation: Numata M, Oshima T. Significance of regenerating islet-derived type IV gene expression in gastroenterological cancers. World J Gastroenterol 2012; 18(27): 3502-3510
URL: https://www.wjgnet.com/1007-9327/full/v18/i27/3502.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i27.3502