Acute pancreatitis in aging animals: Loss of pancreatitis-associated protein protection?

Figure 7 Immunohistochemical staining for pancreatitis-associated protein 1 and 2, high power (100×). Young animals (A, C) are compared to older (B, D). A decreased intensity of staining is observed in aging, and while pancreatitis-associated protein (PAP)1 staining in younger animals is uniform, in older animals it is heterogenous. In contrast, while PAP2 staining patterns are heterogenous in younger animals, they are more uniform in older ones. Note the clumping of PAP2 within the cells of the younger animals, which is absent in the older group.