Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation

Table 2 Histopathological findings of gallbladders from patients with pancreaticobiliary maljunction without biliary dilatation diagnosed based on gallbladder wall thickening on ultrasound

Case	Thickness of the wall (mm)	Mucosal height (mm)	Hyperplastic change	Hypertrophic muscular layer	Subserosal fibrosis	Adenomyomatosis	Gallstone	Ki-67 labeling index (%)	K-ras mutation
1	7	2.4	+a	-	+	-	-	8	GAT (3+)
2	6	1.8	+	-	+	+	-	5	NA
3	3	0.6	-	-	-	-	+	6	-
4	5	2.2	+	+	+	+	-	4	-
5	5	1.7	+	+	+	+	-	5	NA
6	8	1.9	+	+	+	+	-	8	AGT (1+)
7	6	1.4	+	+	+	-	+	9	AGT (2+)
8	25	0.9	+	+	+	+	-	3	-
PBM, %,	7.7 ± 7.0b	1.06 ± 0.7b	88 (7/8)b	63 (5/8)b	88 (7/8)b	63 (5/8)b	25 (2/8)	6.0 ± 2.1b	50 (3/6)a
mean ± SD
Controls, %,	2.0 ± 0.5	0.58 ± 0.24	0 (0/10)	0 (0/10)	0 (0/10)	0 (0/10)	10 (1/10)	1.2 ± 0.3	0 (0/10)
(n = 10),
mean ± SD

PBM: Pancreaticobiliary maljunction; NA: Not amplified.

^aP < 0.05,

^bP < 0.01 vs controls.