Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl4-treated mice

Figure 2 Collagen staining with Sirius red and Hyp content. A: Collagen staining. Week 0 control mice have limited collagen in the portal area, but fibrous septa bridging the portal tracts were found in the livers of CCl₄-treated mice, and this was significantly attenuated in YGJ-treated mice, × 200; B: Semi-quantification of collagen staining, the week 0 control group level was set as the basal level; C: Hyp content in the liver. Results of collagen staining and Hyp content show that they both continuously increased in the CCl₄-treated group but declined in the YGJ + CCl₄ group over the entire period. ^aP < 0.05, ^bP < 0.01 vs week 0 control group; ^cP < 0.05, ^dP < 0.01 vs the same time-point CCl₄ group. Results are presented as mean ± SD. CCl₄: Carbone tetrachloride; YGJ: Yiguanjian; Hyp: Hydroxyproline.