Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis

Figure 6 Effects of the 4th fraction of Nardostachys jatamansi on interleukin 1, interleukin 6, and tumor necrosis factor during cerulein-induced pancreatitis. Mice pretreated with Nardostachys jatamansi (NJ) were challenged with intraperitoneal injections of cerulein at a supramaximal dose (50 μg/kg). Mice were killed at 6 h after the last cerulein injection. Levels of serum cytokines were measured by enzyme-linked immunosorbent assay (A). Levels of pancreatic mRNA for interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α were quantified using real-time reverse transcriptase polymerase chain reaction (B). Data show the mean ± SE for 6 mice in 1 group. The results were similar in 3 additional experiments. ^aP < 0.05 vs the saline treatment; ^cP < 0.05 vs cerulein treatment alone. AP: Acute pancreatitis.