Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivo

Figure 3 Local injection of liver-intestine cadherin-RNA interference-lentivirus suppresses the growth of established tumors in nude mice. A, B: Representative photographs of one mouse in each group 1 wk after the final injection of green fluorescent protein (GFP)-lentivirus or liver-intestine cadherin (CDH17)-RNA interference (RNAi)-lentivirus; C, D: Representative photographs of tumors isolated from one mouse in each group 1 wk after the final injection of GFP-lentivirus or CDH17-RNAi-lentivirus; E, F: Hematoxylin-eosinstaining of xenotransplanted tumors: Ccontrol group (E); CDH17-RNAi-lentivirus-treated group (F); G, H: Immunohistochemistry showed knockdown of CDH17 by intratumoral injection of CDH17-RNAi-lentivirus (SP × 200).