Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivo

Figure 1 Tumorigenicity is inhibited by knockdown of liver-intestine cadherin using Lenti-microRNA in BGC823 cells. A: Knockdown of liver-intestine cadherin (CDH17) in lenti-CDH17-miR-B cells was confirmed by western blotting; B: The primary orthotopic tumor volume in the lenti-CDH17-miR-B group was much lower than that of the BGC823 and lenti-CDH17-miR-neg groups during the observation periods (^aP < 0.05). Data represent the mean ± SD (n = 6). P-values for the indicated comparisons were determined with one-way analysis of variance.