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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 28, 2012; 18(24): 3050-3057
Published online Jun 28, 2012. doi: 10.3748/wjg.v18.i24.3050
Published online Jun 28, 2012. doi: 10.3748/wjg.v18.i24.3050
Table 2 Studies showing association between achalasia and human leukocyte antigen
| Authors | Allele | Allele frequency, n/N (%) | Pc value | Autoantibody in achalasia, n/N (%) | P value | ||
| Achalasia | Control | AM positive | AM negative | ||||
| Ruiz-de-León et al[34] | DQA1*0103 | 27/92 (29.3) | 40/275 (14.5) | < 0.02 | 22/50 (44) | 5/42 (20) | < 0.02 |
| DQB1*0603 | 23/92 (25) | 33/275 (12) | 0.05 | 19/50 (38) | 4/42 (10) | 0.05 | |
| Latiano et al[40] | DQB1*0502 | (10.2) | (4.1) | 0.016 | Antineuronal antibodies:10/41 (24.4) in achalasiaNone in controlsBoth HLA risk allele and antibody: in one patientNone in controls | ||
| DQB1*0601 | (5.93) | (0.51) | 0.001 | ||||
| DQA1 | - | - | NS | ||||
- Citation: Ghoshal UC, Daschakraborty SB, Singh R. Pathogenesis of achalasia cardia. World J Gastroenterol 2012; 18(24): 3050-3057
- URL: https://www.wjgnet.com/1007-9327/full/v18/i24/3050.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i24.3050