Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth

Figure 4 Stem cell factor stimulates gastrointestinal stromal tumors cell proliferation in vitro. Gastrointestinal stromal tumor (GIST) primary cells were incubated for 72 h with exogenous stem cell factor (SCF) (0-100 ng/mL, A) or KIT immunoblocking antibody (100 ng/mL, B), cell proliferation was analysed by methyl thiazolyl tetrazolium assay. The data are presented as the mean ± SD (n = 4 for each). ^aP < 0.05, ^bP < 0.01 vs untreated cells.