Potential prospects of nanomedicine for targeted therapeutics in inflammatory bowel diseases

Figure 2 Nanomodulations whose efficacy has been validated in animal models of inflammatory bowel diseases. Genes regulated therapeutically by nano gene silencing in intestinal tissues and macrophages and protein nanobodies that have been investigated to have therapeutic impacts to help control inflammation and tissue destruction in animal models relevant to inflammatory bowel diseases (IBDs). TNF: Tumor necrosis factor; Map4k4: Mitogen-activated protein kinase kinase kinase kinase 4; MMP: Matrix metalloproteinase; NF-κB: Nuclear factor kappa B.