Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

Table 3 Univariate and multivariate analyses of variables associated with tumor-free survival and overall survival

Variables	TFS				OS
	Univariate P	Multivariate			Univariate P	Multivariate
		Hazard ratios	95% Cl	P		Hazard ratios	95% Cl	P
Child-Pugh (A/B)	0.184	NA	NA	NA	0.034	1.342	1.016-1.747	0.041
Tumor differentiation (high/intermediate/low)	0.037	1.213	0.743-1.980	0.441	0.038	1.133	0.683-1.679	0.624
Tumor number (≥ 2/1)	0.021	1.012	0.675-1.517	0.354	0.040	1.107	0.732-1.575	0.630
ECOG PS (0/1/2)	0.078	NA	NA	NA	0.045	1.079	0.893-1.530	0.679
MACC1 (low/high)	< 0.001	1.489	1.071-1.801	0.013	< 0.001	1.508	1.079-1.835	0.012
MACC1 and c-Met expression (both/one)	< 0.001	1.929	1.207-3.083	0.006	< 0.001	1.539	1.172-2.208	0.010

TFS: Tumor-free survival; OS: Overall survival; ECOG PS: Eastern Cooperative Oncology Group Performance Status Scale; MACC1: Metastasis-associated in colon cancer 1; NA: Not applicable.