Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan

Table 2 Correlation of histologic grade with clinical factors and tumor characteristics n (%)

	Low-grade (n = 34)	High-grade (n = 12)	P value1
Age	61.7 ± 8.4	56.5 ± 6.7	0.055
Sex			0.260
M/F	32 (94.1)/2	10 (83.3)/2
Etiology of liver disease			0.431
HBV/HCV/alcohol/unknown	21/2/2/9	9/0/1/2
AFP (ng/mL)	2892.0 ± 9255.6	2960.5 ± 9554.0	0.930
<200/≥ 200	26 (76.5)/8	10 (83.3)/2
PIVKAII (mAU/mL) (n = 20/n = 7)	758.4 ± 823.1	798.6 ± 879.6	1.000
< 40/≥ 40	3 (15)/17	1 (16.7)/6
Tumor morphology			0.441
Nodular/infiltrating	24 (70.6)/10	8 (66.7)/4
Tumor size			0.643
< 5/≥ 5	16 (47.1)/18	7 (58.3)/5
Tumor number			0.297
1/≥ 2	20 (58.8)/14	9 (75)/3
PVTT			0.259
Yes	8 (23.5)	1 (8.3)
Child-Pugh classification			0.563
A/B/C	30 (88.2)/4/0	11(91.7)/1/0
T stage			0.537
1/2/3/4	3/15/9/7	1/7/2/2
SUV
Isometabolism	14 (41.2)	2 (16.7)	0.061
Hypometabolism	2	0
Hypermetabolism (n = 18/n = 10)
Maximum	3.75 ± 0.74	5.75 ± 2.15	0.027
Average	3.30 ± 0.42	4.15 ± 1.17	0.226
TNR (SUV ratio)	1.33 ± 0.22	1.64 ± 0.52	0.286

HBV: Hepatitis B virus; HCV: Hepatitis C virus; AFP: α-fetoprotein; PIVKAII: Protein induced by vitamin K antagonist II; PVTT: Portal vein tumor thrombosis; SUV: Standardized uptake value; TNR: Tumor-to-nontumor ratio.

¹Statistical significance test was done by U test.