Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan

Table 1 Patients baseline characteristics

	n = 138	%
Age	59.6 ± 11.1 (range: 33-84)
Sex
M/F	114/24	82.6/17.4
Etiology of liver disease
HBV/HCV/alcohol/unknown	89/15/10/24	64.5/10.9/7.2/17.4
AFP (ng/mL)	9512.9 ± 23 026.4
PIVKAII (mAU/mL)	854.2 ± 871.7
Tumor morphology
Nodular/infiltrating	78/60	56.5/43.6
Tumor size (mm)	69.8 ± 45.2
Tumor number
1/≥ 2	52/86	37.7/62.3
PVTT
Yes	54	39.1
Child-Pugh classification
A/B/C	77/56/5	55.8/40.6/3.6
Tumor stage1
I/II/III/IVa/IVb	7/34/26/22/49	5.1/24.6/18.8/15.9/35.5
SUV
Iso-/hypometabolism	42/3	30.4/2.2
Hypermetabolism	93	67.4
Maximum	5.32 ± 2.38
Average	4.03 ± 1.26
TNR (SUV ratio)	1.60 ± 0.49
Extrahepatic metastases	50	36.2
Lung	23	46.0
Lymph nodes	22	44.0
Bone	11	22.0
Others2	5	10.0

¹Tumor stage based on the Modified Union for International Cancer Control Tumor Node Metastasis staging system;

²Others: Adrenal gland, peritoneal carcinomatosis, Morrison’s pouch. HBV: Hepatitis B virus; HCV: Hepatitis C virus; AFP: α-fetoprotein; PIVKAII: Protein induced by vitamin K antagonist II; PVTT: Portal vein tumor thrombosis; SUV: Standardized uptake value; TNR: Tumor-to-nontumor ratio.