Intervention of Mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts

Table 2 Effects of Mirtazapine on tumor size, pancreatic tumor weight and food intake

Effects on tumor size (mL)
Group	5 d	9 d	13 d	17 d	21 d	25 d	28 d
Control group	37.67 ± 7.57	62.59 ± 24.06	105.39 ± 19.92	174.77 ± 15.16	258.54 ± 20.98	365.58 ± 17.63	472.62 ± 13.03
Mirtazapine group	37.12 ± 10.55	58.09 ± 26.00	100.21 ± 21.87	171.57 ± 16.94	246.88 ± 25.64	357.80 ± 15.75	466.95 ± 14.21
P value	0.926	0.748	0.638	0.726	0.376	0.411	0.454
Effects on pancreatic tumor weight (g)
Group	Mice body weight (Tumor-bearing) (g)		Mice body weight (Tumor removed) (g)		Tumor weight (g)	P value
Control group	16.04 ± 0.66		15.61 ± 0.59		0.42 ± 0.09	0.35
Mirtazapine group	16.89 ± 0.73		16.51 ± 0.63		0.37 ± 0.11
Effects on food intake
Group	Basic line	7 d	14 d	21 d	28 d
Control group	5.15 ± 0.12	5.13 ± 0.13	4.21 ± 0.10	3.54 ± 0.10	3.02 ± 0.16
Mirtazapine group	5.17 ± 0.15	5.19 ± 0.14	4.41 ± 0.16	3.95 ± 0.14	3.57 ± 0.11
P value	0.917	0.544	0.054	0.004	0.003